MARKETS
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APOLLO NEWSLETTER
Professor Paul
Zimmet
AO
Head of
International Diabetes Institute, Melbourne
"The data that I have seen so far makes this one of the most forward looking and best prospects of an oral insulin"
Click here to see Paul Zimmet's view on Apollo's oral insulin
Bill Moss AM
Non-Executive Director and
Investor
"Apollo has a number of opportunities to grow into the future. Opportunities perhaps that are much greater than many other companies many times their size"
Click here to hear Bill Moss's view on investing in Apollo
Markets

Apollo develops products to meet the needs of three customer segments:

1) patients requiring prescribed treatments
2) individuals with conditions that can be alleviated by over-the-counter treatments
3) scientists using proteins for research and development.

In the therapeutics market, Apollo develops treatments across a wide range of disease markets which currently lack convenient and/or effective treatments. Product benefits stem from the combination of Apollo's technology platforms, which can deliver water and oil soluble molecules up to antibody size in a tablet or topical (skin) application, and its large library of natural human (hcx™) proteins. Together these provide a foundation to create potentially transforming treatments.

Apollo focuses primarily on therapeutic markets for protein-based drugs (biopharmaceuticals). The market for biopharmaceuticals has an estimated value of US$50 billion per annum and 10% annual growth. The market for TNF blockers - just one category of biopharmaceuticals used to treat conditions such as rheumatoid arthritis and psoriasis - is estimated to be worth US$10 billion a year. Bio-pharmaceuticals, which use proteins or antibodies instead of synthesised chemical compounds, are a growing class of therapeutics for diseases ranging from cancer to inflammation and autoimmunity. Proteins and antibodies together made up approximately 57% of the new biopharmaceutical entities approved by the US Food and Drug Administration (FDA) in 2005.

Apollo's initial development focus is on the diabetes and inflammation therapeutic markets.

Disease
Apollo candidate
Accessible
 market
Growth
$pa
% pop
Diabetes Oral insulin
$18 billion
40%
4%
Psoriasis Topical TNF blocker
$3 billion
24%
3%
Arthritis Oral TNF blocker
$7 billion
36%
3%
Arthritis Topical TNF blocker

Apollo is also developing products for two other markets in order to generate early cash flow.

In the Over-the-Counter (OTC)/Wellness market, Apollo applies its oral and transdermal delivery platforms and knowledge of skin and inflammatory conditions to develop products that are available without prescription.

Apollo is leveraging its natural human protein technology by selling a large range of research grade proteins and detection kits to science researchers in universities, research institutes and companies. The total market for research proteins is US$400 million per annum. Initial sales and distribution for both markets are primarily via the web.