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APOLLO NEWSLETTER
Professor Paul
Zimmet
AO
Head of
International Diabetes Institute, Melbourne
"The data that I have seen so far makes this one of the most forward looking and best prospects of an oral insulin"
Click here to see Paul Zimmet's view on Apollo's oral insulin
Bill Moss AM
Non-Executive Director and
Investor
"Apollo has a number of opportunities to grow into the future. Opportunities perhaps that are much greater than many other companies many times their size"
Click here to hear Bill Moss's view on investing in Apollo
Research Proteins

Apollo markets the world’s largest range of human cell-expressed (hcx™) recombinant proteins (www.apollocytokineresearch.com) to universities and research centres, pharmaceutical companies, diagnostic and imaging companies and other organisations. The pipeline is being updated continually. Distribution worldwide is primarily via the web. Click here for a list of products.

Proteins are widely used in pure and applied biological experiments, because they play a central role in maintaining balance among the body systems needed for the body to survive and function correctly. Worldwide research protein sales are estimated at US$400 million per year, with the market growing at 15 per cent annually.

Benefits of Apollo’s hcx™ proteins

With its large range of tag-free hcx™ proteins expressed from human cells, Apollo is leading the creation of a new market segment for recombinant proteins that are most physiologically relevant to human biological systems. Many offer heightened sensitivity when used in diagnostics. They also offer the benefit of being scalable to clinical trial and therapeutic quantities.

The benefits occur because the hcx™ proteins closely resemble native human proteins, as a result of being expressed from human cells (Human proteins, human source™). More

By contrast, other commercially available recombinant human proteins typically do not mirror native human proteins because their non-human source means they lack human attachments (post-translational modification-PTMs). Although native human proteins can be obtained by extraction from human tissues (eg blood platelets, urine), such sources are not suitable for generating therapeutic quantities.

   DNA
Expression System
            rh Protein
Proteins expressed in E. coli don't have some PTMs such as glycosylation
Apollo's hcx™ proteins have human PTMs making them more human

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Competitive advantages of Apollo’s hcx™ proteins
Apollo is the only company that produces a large range of proteins expressed from human cells.

Product matrix: Human proteins for research use



To ensure that the hcx™ proteins are as close to the natural form as possible, Apollo makes the extra effort to purify its proteins without tags, and actively investigates the biological function and sugar structures (glycosylation) of its extensive range of hcx™ proteins. Researchers are provided with distinctive product documentation that highlights the differences from recombinant human proteins expressed from non-human source cells. See example

Research, pharmaceutical, diagnostic and imaging organizations can purchase Apollo’s human-expressed cytokines for research use here: Click here

Further reading

 

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